KL and chronic kidney disease: Table 2 lists some of the anti-aging characteristics of the Klotho protein [21]. In contrast, low levels of the glycoprotein fetuin-A, whose function is to bind calcium and prevent calcification, co-occur with telomere shortening. Unfortunately, the function of both systems in CKD is impaired by hypercalcemia, hyperphosphatemia or hyperparathyroidism [23].