The presence of CGRP-ir neurons in orthotopic oral cancer HSC-3 and OSC-20 xenografts was confirmed using multiplex immunofluorescence staining for CGRP, GAP43 (marker of sprouting neurons), SOX10 (expressed in Schwann cell nuclei), PECAM (blood vessel marker), LYVE1 (lymphatic vessel marker) and TRP63 isoforms (epithelial cells) (Figure 1). The gene discussed is GAP43; the disease is lip and oral cavity carcinoma.