PFKFB3 and neoplasm: Moreover, p-PFKFB3 protein levels were only completely depleted in p38γ-expressing KPC tumor cells by a combination of the p38γ inhibitor PFD with the PFKFB3 inhibitor PFK15, and expression of the phosphorylation mutant PFKFB3/S467A in KPC tumors decreased the tumor growth in nude mice, as compared to the tumor expressing wild-type PFKFB3.