PFKFB3 and familial pancreatic carcinoma: In pancreatic cancer, p38γ binds phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (PFKFB3) in KRAS-transformed cells and phosphorylates PFKFB3 at S467 in human pancreatic cancer cells and in mouse KPC tumors [32].