Among them, ARG1 and CPS1 genes exhibit the most significant down-regulation, whose log2 ratios by comparison between IHCC and non-tumor, as well as IHCC and normal bile duct, are −4.0505 and −2.9184 (p ≤ 0.0001) and −3.9435 and −2.8787 (p ≤ 0.0002), respectively. This evidence concerns the gene CPS1 and neoplasm.