In addition to reports related to platelet activation [34] such as DIC [29], TMA [30], and hypercoagulability such as nephrotic syndrome [36] and colorectal cancer [37], it was reported that CLEC-2 regulates inflammatory reactions [38,39,40] and CLEC-2 may be related to cancer progression with platelet activation and hypercoagulability [37,41]. This evidence concerns the gene CLEC1B and thrombophilia.