Secondly, another characteristic of excess AT that is linked to the inflammatory imbalance of obesity is the abnormality in the production of adipokines, such as the upregulation of proinflammatory adipokines (leptin) and the downregulation of anti-inflammatory adipokines (adiponectin), which aggravates cerebrovascular and cardiovascular diseases and insulin resistance [20]. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.