SERPIND1 and Venous thrombosis: EG affects rheology by maintaining vascular permeability and vascular tone, regulating fluid balance, preventing microvascular thrombosis and adjusting leukocyte adhesion, influencing hemodynamics and coagulation function.[19] HS and DS in EG bind to anticoagulant substances (antithrombin, heparin cofactor and tissue factor) in the organism to inhibit activation of thrombin and activation factors IX, X, heparin cofactor II, VIIa and Xa, the integrity of EG is, therefore, critical to maintain normal coagulation function.[8]