FOXD3 and neoplasm: Long noncoding RNAs (lncRNAs) are unable to translate proteins directly; instead, they regulate the transcriptional, translation and modification of genes, which has a significant impact on the development and progression of malignant tumors.[8] Zhang et al found that lncRNA FOXD3-AS1 could promote tumor development and metastasis by miR-127-3p/ARF6 axis in BRCA.[9] Xu et al found lncRNA Uc003xsl could activate an epigenetic-driven NFκB/IL8 cascade thus contribute to tumor metastasis and poor survival in triple-negative BRCA patients.[10]