In a study where HCV/RNA (+) patients were treated with SOF plus RBV with or without peginterferon-alfa for 12 weeks anemia and leucopenia occurred.[25] In addition, hematologic abnormalities were more prominent among the triple-therapy group in other studies, for example, Satsangi et al,[32] and Wei et al[33] Adding IFN to other DAAs was associated with anemia and leucopenia in other studies.[37,38] In contrast to our study, Ahmed et al found no significant effect of adding IFN to a SOF--RBV regimen on hemoglobin and leucocyte levels.[31]. Here, IFNA1 is linked to anemia (phenotype).