This is intimately connected to the primary ferroptosis pathways GPX4 and FSP1.GPX4 is the main role In GSH‐Px, FSP1 indirectly suppresses ferroptosis via vitamin E. In the present study, we suggest that APAP inhibits ferroptosis in mice with sepsis via the GPX4 and FSP1 pathways. The gene discussed is GPX4; the disease is Sepsis.