Moreover, higher PBF was associated with higher serum CRP concentrations within HC group (r = 0.58, p < 0.001) but not the MDD group (r = 0.15, p = 0.155), and there was a slope difference on PBF and CRP concentration between HC and MDD (p = 0.034); Similarly, higher BMI was associated with higher serum CRP concentrations within HC group (r = 0.57, p < 0.001) but not within the MDD group (r = 0.16, p = 0.139), and there was a slope difference on BMI and CRP concentration between HC and MDD (p = 0.018). This evidence concerns the gene CRP and major depressive disorder.