Among DE-mRNAs, we observed genes previously reported in facilitating BC cell migration and proliferation (CEMIP) [48], BC bone metastasis formation (IL6R) [49, 50] and/or bone remodelling (SUMO3, POLDIP2) [51, 52] (Fig. 6a and Supplementary Fig. S16), reinforcing our experimental results. This evidence concerns the gene SUMO3 and breast cancer.