The evidence of attenuated bone metastasis at an early stage was further supported by the in vitro demonstration that conditioned media from BC cells overexpressing miR-662 mimics inhibited osteoclast differentiation of murine and human peripheral blood mononuclear cells treated with M-CSF and RANKL, compared to negative control mimics (Fig. 4). The gene discussed is TNFSF11; the disease is breast cancer.