Compared to biomarkers altered by amyloidosis that are often abnormal in older cognitively normal individuals, CSF MTBR-tau243 could enable confirmation of tau pathology and provide greater certainty that cognitive symptoms are due to AD, as proposed in the latest clinical AD criteria requiring biomarker evidence of both amyloid and tau pathology to diagnose AD with high likelihood58. The gene discussed is MAPT; the disease is amyloidosis.