We found that p300 expression was upregulated in the cardiac tissues of patients and mice with heart failure, as well as in Ang II-treated H9c2 cells (Supplementary information, Fig. S4g–m), but the interaction between p300 and α-MHC was not changed in H9c2 cells and mouse myocardial tissues, regardless of Ang II stimulation (Fig. 3g, h). Here, EP300 is linked to heart failure.