IL10RA and acute respiratory distress syndrome: To explore the role of IL-10 in ALI, we used IL-10 or IL-10 receptor (IL-10R) monoclonal antibodies to block IL-10 signaling in a murine LPS-induced ALI model (anti-IL-10/anti-IL-10R mice) and found that anti-IL-10/anti-IL-10R mice had more severe and persistent clinical symptoms (Fig. 1A, B).