IL10RA and infection: We found that blocking IL-10 or IL-10R increased body weight loss in mice and reduced their recoverability from lung inflammation and alveolar damage, suggesting that IL-10 signaling is required for timely resolution of lung injury, consistent with the ability of IL-10 in limiting fatal tissue damage during several experimental models of infection, including Toxoplasma gondii, malaria, and Trypanosoma cruzi [21].