Importantly, by immunohistochemical (IHC) staining of xenograft tumor tissues, we found that knocking down ACTL6A expression significantly decreased the level of Ki67, a proliferation marker, and increased that of 4-hydroxy-2-noneal (4-HNE)45, a lipid peroxidation marker (Fig. 3i). This evidence concerns the gene ACTL6A and neoplasm.