TLR4 and lung carcinoma: Moreover, stimulation with TLR4 and TLR3 can induce the production of IL-6, CCL2/MCP-1, CCL20/MIP-3α, VEGFA (vascular endothelial growth factor A), and MMP2 known to play pivotal roles in the migration and invasion of lung cancer cells through induction of autophagy [13].