Some scholars further investigated [46] found a novel signaling target in DCM, Nek7/GBP5 pathway activates NLRP3 inflammatory vesicles and disrupts cardiac structure and neovascularization, while BMP-7 inhibits Nek7/GBP5 pathway activation significantly reduces NLRP3 inflammatory vesicle formation, inflammatory cytokines and inflammatory cell infiltration, improving cardiac remodeling and function in DCM. This evidence concerns the gene NEK7 and familial dilated cardiomyopathy.