Tripartite motif‐containing (TRIM) family proteins as regulators are involved in both autophagy and pyroptosis, while they play critical roles in diabetes mellitus and its complications [24].TRIM27 [25], TRIM32 [26], TRIM7 [27], TRIM72 [28], TRIM13 [29] and TRIM63 [30] acting as regulatory proteins are involved in the development of DM as well as diabetic complications. The gene discussed is TRIM63; the disease is diabetes mellitus.