Some scholars further investigated [46] found a novel signaling target in DCM, Nek7/GBP5 pathway activates NLRP3 inflammatory vesicles and disrupts cardiac structure and neovascularization, while BMP-7 inhibits Nek7/GBP5 pathway activation significantly reduces NLRP3 inflammatory vesicle formation, inflammatory cytokines and inflammatory cell infiltration, improving cardiac remodeling and function in DCM. Here, NLRP3 is linked to familial dilated cardiomyopathy.