Recent study [42] found that hydrogen inhalation reduces the scorched death inflammatory response and ameliorates fibrosis by inhibiting the AMPK/mTOR/NLRP3 signaling pathway and inhibits the TGF-131/Smad signaling pathway, and that hydrogen in combination with metformin exhibits more effective cardioprotection in the treatment of DCM. This evidence concerns the gene NLRP3 and familial dilated cardiomyopathy.