The frequency of BID copy number gains in COSMIC samples was approximately the same as the frequency of co-amplification of BCL2L13, BID, CRKL and MAPK1 in all histologies with the only exception of pancreatic cancer (Fig. 8A), indicating that copy number gains in BID are almost invariably associated with co-amplification of the other three Chr22q11 genes. Here, CRKL is linked to familial pancreatic carcinoma.