Although VEGF is one of the most important angiogenic drivers, tumors have also evolved bypassing pathways in promoting angiogenesis.30,31 The overexpression or depletion of BICC1 did not affect the mRNA and protein level of VEGFA in PAAD cells, and VEGFA depletion had no effect on BICC1 expression (Fig. 3a–c). This evidence concerns the gene BICC1 and pancreatic adenocarcinoma.