Based on the expression profiles of BICC1 (supplementary Fig. 4a), we transduced the human or mouse BICC1 into PAAD cells with low or moderate BICC1 levels to increase BICC1 expression and transduce shRNA sequences for BICC1 to silence BICC1 expression in PAAD cell with high or moderate BICC1 levels (Fig. 2c, Supplementary Fig. 4b). The gene discussed is BICC1; the disease is pancreatic adenocarcinoma.