BICC1 and neoplasm: CXCL1 is a well-known proangiogenic factor that can mediate VEGF-independent tumor angiogenesis.35,36 As an RNA-binding protein, we found that BICC1 binds to the “AUUUA” sequence in the 3’UTR region of LCN2 mRNA, prolonging the half-life of LCN2 mRNA and thereby upregulating LCN2 expression.