To narrow it down, we selected genes highly expressed in PAAD and negatively correlated with survival.41–43 Although in the present study we have confirmed that upon stimulation of LCN2, 24p3R directly binds to JAK2 and promotes its phosphorylation, the mechanism by which 24p3R specifically binds to JAK2 to promote its dimerization and phosphorylation has not been fully elucidated. This evidence concerns the gene LCN2 and pancreatic adenocarcinoma.