Conditioned media from cells with BICC1 overexpression significantly increased hemoglobin content and vessel density, while BICC1 suppression remarkably decreased these parameters, suggesting a critical pro-angiogenic role of BICC1 in PAAD angiogenesis (Fig. 2i, j, Supplementary Fig. 8). Here, BICC1 is linked to pancreatic adenocarcinoma.