To explore whether DCLK1 in cardiomyocytes performs a contribution to obesity-induced cardiomyopathy, cardiomyocyte-specific DCLK1 knockout mice (DCLK1Myh6-cre) and DCLK1f/f mice that were given LFD or HFD for 20 weeks. The gene discussed is DCLK1; the disease is cardiomyopathy.