DCLK1 and cardiac hypertrophy: The hypertrophy alterations were visible on both a gross inspection of the complete heart and WGA labeling of the cardiac tissues not only in HFD-fed DCLK1f/f mice but also in HFD-fed DCLK1Myh6-cre mice, suggesting that cardiomyocyte-specific DCLK1 knockout is unable to prevent HFD-induced cardiac hypertrophy (Fig. 3A–C).