To date, there is no approved pharmacologic therapy for PCOS because the pathogenesis of PCOS is poorly understood and there is no consensus on the underlying mechanisms, and most drugs, such as oral contraceptives, antiandrogens, insulin sensitizers, and aromatase inhibitors, are used to treat the symptoms of PCOS in an off-label manner [15]. The gene discussed is INS; the disease is polycystic ovary syndrome.