GSK3B and acute liver failure: In an acute liver failure model, GSK3β, which is highly activated, can aggravate liver inflammation and hepatocyte apoptosis in model mice and promote the progression of injury [11]; hepatoprotective drugs can improve hepatocyte apoptosis and iron death through GSK3β/Nrf2, AKT/GSK3β and other pathways and play a hepatoprotective role [12].