This study focuses on the hepatoprotective effects and potential mechanisms of the GSK3β inhibitor TDZD-8 in a mouse model of acute liver failure, the LPS/D-Gal mouse model of liver failure, which is used not only to study acute liver failure but also as a study of fulminant liver failure, acute liver injury and other liver diseases [20, 21]. This evidence concerns the gene GSK3B and Hepatic failure.