NLGN3 is primarily expressed on the postsynaptic terminal of excitatory synapses, but the N-terminal ectodomain of NLGN3 in neurons and OPCs can also be secreted by enzymatic cleavage by the ADAM metallopeptidase domain 10 (ADAM10) [14], and then the cleaved form of NLGN3 promotes glioma cell proliferation through the PI3K-mTOR signaling pathway [13]. The gene discussed is ADAM10; the disease is glioma.