Interestingly, primary tumor volume was similar between WT and Il1b−/− mice (Supplementary Fig. 4A and B), but pulmonary metastasis was significantly decreased in Il1b−/− mice compared with WT mice as shown by H&E staining and qPCR analysis of luc2 (Fig. 3A-C). The gene discussed is IL1B; the disease is neoplasm.