NISCH and Cognitive impairment: Intriguingly, treatment with antihypertensive drug clonidine could reduce the mRNA expression of NISCH and reverse the cognitive impairment caused by overexpressing NISCH. Our results thus describe a novel risk gene NISCH mediated by the human-specific Alu element in the 3p21.1 GWAS locus, and offer a potential new avenue into the therapeutic development in the clinical management of psychiatric patients.