To address this question, we herein generate U251 and U87MG cells with different Alu polymorphisms through CRISPR/Cas9 editing, and reveal that the presence of the Alu element, which predicts a higher risk of schizophrenia and BD, increases the mRNA expression of NISCH. Notably, elevated expression of NISCH is also seen in the postmortem brain tissues from patients with either schizophrenia or BD compared with normal controls. The gene discussed is NISCH; the disease is schizophrenia.