The fully-adjusted model, which included DM, age, sex, BMI, coronary artery disease, COPD/asthma, hypertension, chronic renal failure, WHO-FC, 6MWD, NT-proBNP, RAA, TAPSE, CI, mPAP, PVR, RAP, and SvO2, showed that significant predictors of death were: DM and age (HR: 1.03; 95% CI: 1.01–1.05), 6MWD (HR: 0.997; 95% CI: 0.994–0.998), and RAP (HR: 1.08; 95% CI: 1.03–1.14). This evidence concerns the gene NPPB and chronic kidney disease.