A recent study found a trend toward lower rates of stroke in patients with the lowest estimated glomerular filtration rate (less than 60 mL/min/1.73 m2) (HR: 0.77; 95% CI 0.55–1.08) who used SGLT2 inhibitors [16], but no study has yet shown a lower risk of total stroke in patients with T2D and CKD. The gene discussed is SLC5A2; the disease is chronic kidney disease.