The pituitary adenomas also presented a similar aggressiveness (Knosp 3–4: 26.8% vs. 24.3%; Ki-67: 2% vs. 1%, p = 0.57) and size (microadenoma: 13.1% vs. 16.1%; largest dimension: 18.1 ± 9.0 vs. 17.6 ± 8.4 mm). This evidence concerns the gene MKI67 and pituitary gland adenoma.