Although EGFR-dependent signaling is a normal feature of cells, allowing transduction of information from the microenvironment, EGFR is considered one of the main cancer drivers, with the PI3K-AKT axis and RAS-RAF-MEK-ERK axis representing the main EGFR signaling pathways for cancer cell proliferation, progression, migration and angiogenesis. This evidence concerns the gene AKT1 and cancer.