In colorectal cancer, Sorcin promotes metastasis and EMT via activation of PI3K/AKT signaling [63], while Sorcin silencing increases PTEN levels and decreases the expression of ABCB1, Bcl-2, Survivin, phosphorylated AKT and NF-kB, downstream to PI3K/AKT in nasopharyngeal carcinoma [33], in myeloma [69] and in human lung cancer A549/DDP cells [46]. This evidence concerns the gene PTEN and plasma cell myeloma.