MTOR and colonic neoplasm: However, mice bearing tumors with MTA1 overexpression and subsequent knockdown of ATP5A were more sensitive to the treatment and displayed reduced metastasis (Figure 6G, group 4 versus group 8, and Figure 6H, bottom), demonstrating that inhibition of ATP5A enhances the sensitivity of colon cancer liver metastases to the mTOR inhibitor rapamycin and that this process is MTA1 dependent.