MTA1 and neoplasm: and Roth KG et al.[31, 43] To advance these strategies into clinic, there are some points to be considered, such as how to combinedly suppress OXPHOS and glycolysis in the tumor cells but leave the normal cells unaffected and how to exquisitely identify the tumors highly dependent on ATP from OXPHOS at the genetic and epigenetic levels.[44] With these aims, the value of MTA1 should be further evaluated.