Though there are still some topics that need to be clarified in the future such as how MTA1 regulates glycogen storage and motivation and which interaction domain of MTA1 is the most important domain for regulating ATP production, this research found new regulatory component to the essential “energy powerhouse” in the cell‐ATP synthase complex and discovered new mechanisms through which colon cancer liver metastasis is mediated and “Warburg effect” is refined to accommodate cancer adaptation to tumor microenvironment. Here, MTA1 is linked to malignant colon neoplasm.