Metastasis‐associated antigen 1 (MTA1), as a newly identified ATP synthase modulator by interacting with ATP synthase F1 subunit alpha, facilitates colon cancer liver metastasis by driving mitochondrial bioenergetic metabolism reprogramming and enhancing OXPHOS; therefore, modulating ATP synthase activity and downstream mTOR pathways. Here, MTA1 is linked to colonic neoplasm.