In obese and T2D mice, the abundance of Akkermansia muciniphila in the gut is decreased, and its elevation after BS44 has been reported to reduce fat mass, improve metabolism in mice184, 185 and humans,186 increase thermogenesis by inducing UCP‐1 in BAT, and induce systemic GLP‐1 secretion in mice.187. This evidence concerns the gene GCG and type 2 diabetes mellitus.