GHR and urinary bladder cancer: Firstly, we observed that in cultured mouse bladder cancer cells and mouse fibroblast cells, while compound D was comparable to pegvisomant in suppressing bGH-induced STAT5 phosphorylation downstream of GHR activation, compound G exhibited a clear and profoundly superior GHR inhibition than either pegvisomant or compound D, by almost completely inhibiting the downstream STAT5 phosphorylation (Fig. S4).