Importantly, congenital suppression of GH action has been found to be protective against incidence of several age-associated comorbidities such as cancer, diabetes, cardiomyopathy, glomerulonephritis, and cognitive decline in several mouse models (Ames, Snell, lit/lit, GHR−/−, GH−/−, and more) (8, 9). Here, GH1 is linked to diabetes mellitus.