Examination of clinical data showed that 80% of individuals carrying the rs76438938-T allele had developed chronic hepatitis B and liver cirrhosis (OR = 4.6660, P = 0.0209, Pearson Correlation Analysis; Fig. 1a; Supplementary Table S5), indicating that SNP rs76438938-T in KNG1 significantly enhances the susceptibility of carriers to HBV infection. The gene discussed is KNG1; the disease is cirrhosis of liver.