CD8A and systemic lupus erythematosus: In addition, JSLE patients with a high ApoB:ApoA1 ratio (baseline levels correlated positively to SLE disease activity index) had increased cardiometabolic risk conferred by greater number of CD8+ T-lymphocytes and CD8+ T-lymphocyte transcriptomic profile which expressed a higher number of genes associated with interferon signalling and other processes that contribute to atherosclerosis (193).