Obesity associated with chronic mild inflammation led to elevated inflammatory markers, including C-reactive protein (CRP), Tumour Necrosis Factor-α (TNF-α), interleukin (IL)-6, IL-18, haptoglobin, macrophage inhibitory factor (MIF) and plasminogen activator inhibitor-1 (24). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.