In univariate logistic regression analysis, ApoA-1, Lp(a), RLP-C, Non-HDL-C, ApoA-1/ApoB, CRI-I, CRI-II, TG/HDL-C, RLP-C, AI, AIP, and LCI were positively correlated with the severity of CAD (all P < 0.05), and HDL-C was negatively correlated with the risk of CAD (P < 0.001). The gene discussed is APOA1; the disease is coronary artery disorder.