After adjusting potential confounding factors (age, gender, smoking, diabetes, hypertension, creatinine, uric acid, hs-CRP), except for TG/HDL-C (P = 0.138), other lipid parameters, AI (OR: 1.27, 95% CI:1.15–1.40, P < 0.001), AIP (OR: 2.78, 95% CI: 1.82–4.26, P < 0.001), LCI (OR: 1.01, 95% CI: 1.01–1.02, P < 0.001), CRI-I (OR: 1.10, 95% CI: 1.01–1.20, P = 0.037), and CRI II (OR: 1.24, 95% CI: 1.11–1.40, P < 0.001) were still positively correlated with the risk of CAD (all P < 0.05), and HDL-C was still negatively correlated with the risk of CAD (P < 0.001) (Table 3). The gene discussed is AIP; the disease is Hypertension.