COL8A2 and Fuchs endothelial corneal dystrophy: The pathogenicity of COL8A2 variants NP_005193.1:p.Leu450Trp, NP_005193.1:p.Gln455Lys, and NP_005193.1:p.Gln455Val in the early-onset FECD patients has been confirmed by the results of genetic and molecular studies in native specimens and model systems (13, 38–42).