Therefore, we considered it necessary to perform a systematic review of the variants in the SLC4A11, ZEB1, LOXHD1, and AGBL1 genes in the FECD, taking into account the currently available population frequency information, transcriptomic data, and the results of functional studies to assess their pathogenicity. The gene discussed is ZEB1; the disease is Fuchs endothelial corneal dystrophy.