SHANK3 and Pelizeaus-Merzbacher spectrum disorder: The study revealed differences in white matter structural differences in long fiber tracts across species, with alterations in frontal tracts including the uncinate fasciculus and the inferior fronto-occipital fasciculus as well as the corticostriatal pathway in PMD, and differences in the fronto-occipital association fiber tract and the tract connecting motor cortex to entorhinal cortex in Shank3 mouse model (Jesse et al., 2020).