Moreover, the analysis of the content of stem cell-EVs (human iPSC-derived NSC and adipose-derived mesenchymal stem cells) demonstrated that these vesicles are carriers for proteins and miRNAs associated with neuroprotection and synaptogenesis, as is the case of agrin and neuroplastin; the intranasal administration of such EVs successfully led to increased hippocampal neurogenesis in WT rat and AD mouse brains, respectively 59, 100. This evidence concerns the gene AGRN and Alzheimer disease.