To explore the role of RNF157 in CD4+ T cell differentiation and autoimmunity, Rnf157fl/fl and Rnf157CKO mice were immunized with MOG(35-55) peptide in complete Freund's adjuvant (CFA) and treated with pertussis toxin (PTX) to induce EAE. This evidence concerns the gene RNF157 and Autoimmunity.