The trans-BRB delivery of plasmids encoding wild type p53 and Rb94 induced apoptosis of intraretinal retinoblastoma xenografts 44, 77, whilst immunoliposomes loaded with PEDF protein successfully inhibited progression of CNV over the course of a week, requiring daily systemic injection followed by ocular sonication 76. The gene discussed is TP53; the disease is retinoblastoma.