Possibly, chemotherapy drugs and X-ray irradiation may induce autophagy with different mechanisms in GBM, suggesting that although our current study observed the SDC1-TGM2-FLOT1-BHMT copolymer mediating radioresistance in GBM cells by promoting autophagic flux, it remains to be further explored whether this tetramer plays a similar role in the process of autophagy induced by other stimuli in other types of tumors. Here, SDC1 is linked to glioblastoma.