HMGB1 and Sepsis: Considering that lactate increased HMGB1 lactylation and secretion of macrophage during sepsis 10, it is possible, therefore, that HSPA12A modulates glycolysis-derived lactate to affect HMGB1 lactylation and secretion from hepatocytes, by which changes macrophage chemotaxis and activation, and finally affects LI/R injury.