Additionally, with the development of MI, the mRNA expression of RMST and fibrotic genes, including collagen type I alpha 1 (Col1a1), collagen type III alpha 1 (Col3a1), alpha-smooth muscle actin (α-SMA), and fibronectin 1, was progressively upregulated in different phases of cardiac remodeling in the BZ of MI hearts compared with sham hearts (Figure 1B-F), indicating that RMST expression may be related to fibrotic progress. This evidence concerns the gene COL3A1 and myocardial infarction.