EPHB6 and colitis: In this study, we used a DSS-induced mice acute colitis model to explore the potential mechanism of oat beta-glucan in reducing experimental colitis and a lipopolysaccharide-induced HT-29 cells inflammation model to explore the role of the EPHB6-TFEB axis in the mechanism of oat beta-glucan in reducing experimental colitis, hoping to provide more evidence to support the prevention or treatment of IBD with oat beta-glucan (Figure 1).