PPARG and Myocardial fibrosis: The oral administration of curcumin in spontaneously hypertensive rats significantly reduced the expression of connective tissue growth factor, type III collagen, and fibronectin in the left ventricle of the heart and upregulated peroxisome proliferator-activated receptor gamma (PPARγ) activity, thereby alleviating hypertension-induced myocardial fibrosis (Meng et al., 2014).