While orexin-A regulates sleep and wakefulness, and at the same time acts as an anti-inflammatory neuropeptide to participate in the protection of neurodegeneration, it can also reduce neuroinflammation after intracerebral hemorrhage in mice through the OXR2/CaMKKβ/AMPK signaling pathway (24). Here, HCRTR2 is linked to intracerebral hemorrhage.