Leptin, adiponectin, resistin, visfatin, omentin, and inflammatory cytokines (such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1)) are just some of the known hormones that are released by adipocytes in both obesity and diabetes (175, 176). Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.