Glucose and lipid metabolism disorders not only induce mitochondrial dysfunction by increasing the expression of the mitochondrial fission-related proteins mitochondrial adaptor Fis1 and Drp1/p-Drp1 (78) but also promote protein kinase Cδ (PKCδ)/Drp1 signal transduction, which can trigger hexokinase II (HK-II) dissociated from mitochondria and downregulate the HK-II/PINK1/Parkin pathway to inhibit mitophagy and aggravate endothelial injury (101). Here, HK2 is linked to Disorder of lipid metabolism.