In addition, treatment of the 143B OS mouse model with IL‐24 revealed inhibition of the tumor growth rate and downregulation of Notch 1, Hes 1, and β‐catenin expression in xenograft tumor tissues, suggesting that IL‐24 may be a new target to improve long‐term survival of patients with OS.243. This evidence concerns the gene NOTCH1 and neoplasm.