PIK3CA and neoplasm: Additionally, multiple factors including drugs, proteins, RNA, and genes either positively or negatively regulate tumor cells proliferation, invasion, and apoptosis in OS by affecting the signaling pathways JAK/STAT3, Hippo, Wnt/β‐catenin, PD‐1/PD‐L1, Notch, MAPK, PI3K/AKT/mTOR, NF‐κB, and others (Figure 1).